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Markus Loeffler, MD

  • Specialties

    Trauma, Pelvic & Acetabular Fractures, Periarticular Fractures, Complex Joint Reconstruction

  • Fellowship

    Orthopedic Trauma - Stanford University

  • Residency

    Prisma Health/University of South Carolina

  • Medical School

    Boston University School of Medicine

About Markus Loeffler, MD

Dr. Markus Loeffler received his medical degree from Boston University School of Medicine.  He then went on to complete orthopedic surgery residency at Prisma Health/University of South Carolina in Greenville, South Carolina.  Following residency he went on to complete an orthopedic trauma fellowship at Stanford University where he received further subspecialty training in the treatment of complex orthopedic injuries.

His primary focus is treatment of the polytraumatized patient with a particular interest in pelvic and acetabular fractures, periarticular fractures, and complex joint reconstruction following trauma.  He is a member of the Orthopedic Trauma Association and is interested in teaching and mentoring prospective orthopedic traumatologists.


  • Northcutt, A. et al. (2011). Novel toll like receptor 4 (TLR4) involvement in drug reward. Brain, Behavior, and Immunity, 25, S189-S189, doi: 10.1016/j.bbi.2011.07.040

  • Menendez, M. E., Loeffler, M., & Ring, D. (2015). Patient Satisfaction in an Outpatient Hand Surgery Office: A Comparison of English- and Spanish-Speaking Patients. Quality Management in Health Care, 24(4), 183–189.

  • Adams JD Jr, Loeffler MF. Soft Tissue Injury Considerations in the Treatment of Tibial Plateau Fractures. Orthop Clin North Am. 2020 Oct;51(4):471-479. doi: 10.1016/j.ocl.2020.06.003. Epub 2020 Aug 12. PMID: 32950216.

  • Slobogean G.P., Sprague S., Wells J., Bhandari M., Rojas A., Garibaldi A., et al. Effectiveness of Iodophor vs Chlorhexidine Solutions for Surgical Site Infections and Unplanned Reoperations for Patients Who Underwent Fracture Repair: The PREP-IT Master Protocol. JAMA network open. 2020 Apr 1;3(4):e202215. PMID: 32259266 (Loeffler, Markus F., Collaborator- Greenville, SC)

  • Sprague S, Scott T, Dodds S, Pogorzelski D, McKay P, Harris AD, Wood A, Thabane L, Bhandari M, Mehta S, Gaski G, Boulton C, Marcano-Fernández F, Guerra-Farfán E, Hebden J, O'Hara LM, Slobogean GP; PREP-IT Investigators. Cluster identification, selection, and description in cluster randomized crossover trials: the PREP-IT trials. Trials. 2020 Aug 12;21(1):712. doi: 10.1186/s13063-020-04611-9. Erratum in: Trials. 2020 Sep 30;21(1):821. PMID: 32787892 (Loeffler, Markus F., Collaborator- Greenville, SC)

  • Lin CA, O’Hara NN, Sprague S, O’Toole RV, Joshi M, Harris AD, et al. Low Adherence to Recommended Guidelines for Open Fracture Antibiotic Prophylaxis. The Journal of bone and joint surgery American volume. 2021 Jan 7; Publish Ahead of Print. PMID: 33411466 (Loeffler, Markus F., Collaborator – Greenville, SC)

  • Pogorzelski D, Nguyen U, McKay P, Thabane L, Camara M, Ramsey L, et al. Managing work flow in high enrolling trials: The development and implementation of a sampling strategy in the PREPARE trial. Contemporary clinical trials communications. 2021 Jan 23;21:100730. PMID: 33605946 (Loeffler, Markus F., Collaborator – Greenville, SC)

  • Sprague S, Guyatt P, Bzovsky S, Nguyen U, Bhandari M, Thabane L, et al. Pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solution in open fractures (Aqueous-PREP): the feasibility of a cluster randomized crossover study. Pilot Feasibility Studies. 2021 Mar 1;7(61). PMID: 33648577 (Loeffler, Markus F., Collaborator – Greenville, SC)

  • Adams JDJ Jr, Walker JB, Loeffler M. Avoid the In-Out-In Posterosuperior Femoral Neck Screw: the Use of the Piriformis Fossa Radiographic Landmark. J Orthop Trauma. 2021 Oct 13. doi: 10.1097/BOT.0000000000002288. Epub ahead of print. PMID: 34653103.

  • Lazarus, D.E. et al., Narcotic Prescription Trends for Common Orthopedic Trauma Injuries Before and After Implementation of Statewide Narcotic Prescription Limits. IRB approved, currently in data collection.

  • Adams, J.D. et al., Serendipitous Post-Operative CT Scans After Pelvic and Acetabular Fracture Surgery. IRB approved, currently in data collection.